略歴

2007年3月 天使大学看護栄養学部 卒業
2010年3月 天使大学 看護栄養学研究科 博士前期課程 修了
2013年3月 北海道大学 医学研究科 博士課程 修了（博士（医学））
2012年4月 北海道大学 医学研究科 研究員（学振特別研究員）
2014年4月 北海道大学 獣医学研究科 研究員（学振特別研究員）
2016年7月 米国カリフォルニア大学サンフランシスコ校 糖尿病センター 研究員
（学振特別研究員・同海外特別研究員）
2020年4月 東京大学 先端科学技術研究センター 代謝医学分野 特任助教
2020年4月 東北大学大学院医学系研究科　分子代謝生理学　准教授　現在に至る

 

代表論文

  1. Yoneshiro T*, Wang Q*, Tajima K, Matsushita M, Maki H, Igarashi K, Dai J, White PJ, McGarrah RQ, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature572: 614–619, 2019 *Equal contribution
  2. Yoneshiro T#, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, Saito M.Recruited brown adipose tissue as an anti-obesity agent in humans. J Clin Invest123: 3404-3408, 2013 #Corresponding author

 

原著論文

  1. Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell182, 563-577.e520, 2020
  2. Tajima K, Ikeda K, Tanabe Y, Thomson EA, Yoneshiro T, Oguri Y, Ferro MD, Poon ASY, Kajimura S. Wireless optogenetics protects against obesity via stimulating non-canonical fat thermogenesis. Nat Commun11: 1730, 2020
  3. Yoneshiro T*, Wang Q*, Tajima K, Matsushita M, Maki H, Igarashi K, Dai J, White PJ, McGarrah RQ, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature572: 614–619, 2019 *Equal contribution
  4. Yoneshiro T*, #, Shin W*, Machida K, Fukano K, Tsubota A, Chen Y, Yasui H, Inanami O, Okamatsu-Ogura Y, Kimura K. Differentiation of bone marrow-derived cells toward thermogenic adipocytes in white adipose tissue induced by the β3 adrenergic stimulation. FASEB J33: 5196-5207, 2019 *Equal contribution, #Corresponding author
  5. Yoneshiro T#, Matsushita M, Saito M. Translational aspects of brown fat activation by food-derived stimulants. Handb Exp Pharmacol251: 359-379, 2019 #Corresponding author
  6. Chen Y, Ikeda K, Yoneshiro T*, Scaramozza A*, Tajima K, Wang Q, Kim K, Shinoda K, Sponton CH, Brown Z, Brack A, Kajimura S. Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature565: 180-185, 2019 (IF=43.070) *Equal contribution
  7. Tajima K, Ikeda K, Chang HY, Chang CH, Yoneshiro T, Oguri Y, Jun H, Wu J, Ishihama Y, Kajimura S. Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nat Metab1: 886–898, 2019
  8. Yoneshiro T, Kaede R, Nagaya K, Saito M, Aoyama J, Elfeky M, Okamatsu-Ogura Y, Kimura K, Terao A. Melinjo (Gnetum gnemon L.) seed extract stimulates brown fat thermogenesis and protects mice against obesity, inflammation, and insulin resistance. Nutr Res58: 17-25, 2018
  9. Yoneshiro T, Kaede R, Nagaya K, Aoyama J, Saito M, Izawa S, Okamatsu-Ogura Y, Kimura K, Terao A. Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Obes Res Clin Pract12: 127-137, 2018
  10. Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Accumulation of systemic succinate controls activation of adipose tissue thermogenesis. Nature560: 102-106, 2018
  11. Elfeky M, Yoneshiro T, Okamatsu-Ogura Y, Kimura K. Suppression by adiponectin of late inflammatory mediator, HMGB1-induced cytokine expression in RAW 264 macrophage cells. J Biochem163: 143-153, 2018
  12. Fuse S, Nirengi S, Amagasa S, Homma T, Kime R, Endo T, Sakane N, Saito M, Yoneshiro T, Kurosawa Y, Hamaoka T. Brown adipose tissue density and seasonal lower outdoor temperature in Japanese men and women with a wide range of age. J Biomed Opt23: 1-9, 2018
  13. Lu X, Altshuler-Keylin S, Wang Q, Chen Y, Sponton CH, Ikeda K, Maretich P, Yoneshiro T, Kajimura S. Mitophagy controls beige adipocyte maintenance through a UCP1-independent mechanism. Sci Signal11: 527, 2018
  14. Yoneshiro T#, Matsushita M, Hibi M, Tone H, Takeshita M, Yasunaga K, Katsuragi Y, Kameya T, Sugie H, Saito M. Tea catechin activates and recruits brown adipose tissue in humans. Am J Clin Nutr105: 873-881, 2017 #Corresponding author
  15. Ikeda K, Kang Q, Yoneshiro T, Camporez JP, Maki H, Homma M, Shinoda K, Chen Y, Lu X, Maretich P, Tajima K, Ajuwon KM, Soga T, Kajimura S. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat Med23: 1454-1465, 2017
  16. Uchida K*, Dezaki K*, Yoneshiro T*, Watanabe T, Yamazaki J, Saito M, Yada T, Tominaga M, Iwasaki I. Involvement of thermo-TRP channels in energy metabolism. J Physiol Sci67: 549-560, 2017 *Equal contribution
  17. Yoneshiro T#, Matsushita M, Nakae S, Kameya T, Sugie H, Tanaka S, Saito M. Brown adipose tissue determines seasonal changes in thermoregulatory responses to cold exposure in humans. Am J Physiol Regul Integr Comp Physiol310: R999-R1009, 2016 #Corresponding author
  18. Saito M, Yoneshiro T, Matsushita M. Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans. Best Pract Res Clin Endoc Metab30: 537-547, 2016
  19. Nirengi S, Homma T, Inoue N, Sato H, Yoneshiro T, Tsuzaki K, Saito M, Sakane N, Kurosawa Y, Hamaoka T. Near-infrared time resolved spectroscopy assessment of changes in human brown adipose tissue density during repeated capsiate intake and intake cessation. J Biomed Opt21: 091305, 2016
  20. Nirengi S, Yoneshiro T, Saiki T, Aita S, Matsushita M, Sugie H, Saito M, Hamaoka T. Evaluation of brown adipose tissue using near-infrared time-resolved spectroscopy. Adv Exp Med Biol876: 371-376, 2016
  21. Nirengi S, Amagasa S, Homma T, Yoneshiro T, Matsumiya S, Kurosawa Y, Sakane N, Ebi K, Saito M, Hamaoka T. Catechin-rich beverage intake for 12 weeks increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women: a randomized controlled trial. SpringerPlus5: 1363, 2016
  22. Hibi M, Oishi S, Matsushita M, Yoneshiro T, Yamaguchi T, Usui C, Yasunaga K, Kubota K, Tanaka S, Saito M. Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans. Int J Obesity40:1655-1661, 2016
  23. Yoneshiro T, Saito M.Activation and recruitment of brown adipose tissue as anti-obesity regimens in humans. Ann Med47: 133-141, 2015
  24. Saito M, Yoneshiro T, Matsushita M. Food ingredients as anti-obesity agents. Trends Endocrinol Metab26: 585-587, 2015
  25. Nirengi S, Yoneshiro T, Sugie H, Saito M, Hamaoka T. A novel simple method for detecting brown adipose tissue using near-infrared time-resolved spectroscopy. Obesity (Silver Spring)23: 973-980, 2015
  26. Matsushita M, Yoneshiro T, Aita S, Kamiya T, Kusaba N, Yamaguchi K, Takagaki K, Kameya T, Sugie H, Saito M. Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue. J Nutr Sci Vitaminol 61: 79-83, 2015
  27. Matsushita M, Yoneshiro T, Aita S, Kameya T, Sugie H, Saito M. Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans. Int J Obesity38: 812-817, 2014
  28. Sugita J, Yoneshiro T, Sugishima Y, Ikemoto T, Uchiwa H, Iwanaga T, Suzuki I, Saito M. Daily ingestion of Grains of Paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. J Nutr Sci Vitaminol60: 22-27, 2014
  29. Yoneshiro T#, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, Saito M.Recruited brown adipose tissue as an anti-obesity agent in humans. J Clin Invest123: 3404-3408, 2013 #Corresponding author
  30. Yoneshiro T, Ogawa T, Okamoto N, Matsushita M, Aita S, Kameya T, Kawai Y, Iwanaga T, Saito M.Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans. Int J Obesity37: 993-998, 2013
  31. Yoneshiro T, Saito M.TRP-activated brown fat thermogenesis as a target of food ingredients for obesity management. Curr Opin Clin Nutr Metab Care16: 625-631, 2013
  32. Saito M, Yoneshiro T. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Curr Opin Lipidol 24: 71-77, 2013
  33. Sugita J, Yoneshiro T, Hatano T, Aita S, Ikemoto T, Uchiwa H, Iwanaga T, Kameya T, Kawai Y, Saito M. Grains of paradise (Aframomum melegueta) extract increase energy expenditure through the activation of brown adipose tissue in men. Br J Nutr110: 733-738, 2013
  34. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. Non-pungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr95: 845-850, 2012
  35. Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, Kawai Y, Akutsu H, Umezawa A, Yasuda K, Tobe K, Yuo A, Kubota K, Saito M, Saeki K. Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab16: 394-406, 2012
  36. Yoneshiro T, Aita S, Matsushita M, Okamatsu-Ogura Y, Kameya T, Kawai Y, Miyagawa M, Tsujisaki M, Saito M. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity (Silver Spring)19: 1755-1760, 2011
  37. Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y, Saito M.Brown adipose tissue, whole-body energy expenditure and thermogenesis in healthy adult men. Obesity (Silver Spring)19: 13-16, 2011
  38. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes58: 1526-1531, 2009

 

所属学会

日本肥満学会、日本栄養・食糧学会、日本生理人類学会、日本栄養改善学会、日本健康医学会、American Society for Nutrition