略歴

1998年3月 東北大学工学部生物化学工学科卒業
2001年3月 東北大学理学研究科化学専攻　博士前期課程修了
2004年3月 東北大学理学研究科化学専攻　博士後期課程修了（理学博士)
2004年6月 秋田大学医学部生理学第一講座　研究員
2008年1月 米国オレゴンヘルスサイエンス大学　生化学・分子生物学部門　研究員
2011年9月 東京大学特任助教（先端科学技術研究センター代謝医学分野）
2012年4月 東京大学助教（先端科学技術研究センター代謝医学分野）
2017年4月 東京大学准教授（先端科学技術研究センター代謝医学分野）
2022年4月 東北大学大学院医学系研究科准教授（分子生理学分野）

 

代表論文

  1. Matsumura Y, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J. Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase. J Biol Chem.(2013) 288, 31069-31079.
    PMID: 23990462
  2. Matsumura Y, Sakai J, Skach WR. Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a. J Biol Chem (2000) 275, 14013-14016
  3. Matsumura Y, Ban N, Ueda K, Inagaki N. Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency. J Biol Chem(2006) 281, 34503-34514.
    PMID: 16959783

 

原著論文

  1. Yoshihiro Matsumura*, Ryo Nakaki, Takeshi Inagaki, Ayano Yoshida, Yuka Kano, Hiroshi Kimura, Toshiya Tanaka, Shuichi Tsutsumi, Mitsuyoshi Nakao, Takefumi Doi, Kiyoko Fukami, Timothy F. Osborne, Tatsuhiko Kodama, Hiroyuki Aburatani, & Juro Sakai* (*corresponding authors) H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-specific DNA Methylation Pauses Adipocyte Differentiation. Molecular Cell (2015) 60, 584-596 [DOI] [Journal Web Sit]
  2. Matsumura Y, Sakai J, Skach WR.Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase. J Biol Chem. (2013) 288, 31069-31079.
  3. Devaraneni PK, Conti B, Matsumura Y, Yang Z, Johnson AE, Skach WR.Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex. Cell (2011) 146, 134-147.
  4. Matsumura Y, David LL, Skach WR.Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation. Mol Biol Cell (2011) 22, 2797-2809
  5. Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, Sorscher EJ, Okiyoneda T, Yates JR 3rd, Lukacs GL, Frizzell RA, Manning G, Gottesfeld JM, Balch WE. Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2010) 6, 25-33
  6. Park SK, Amos L, Rao A, Quasney MW, Matsumura Y, Inagaki N, Dahmer MK.Identification and characterization of a novel ABCA3 mutation. Physiol Genomics (2010) 40, 94-99
  7. Pitonzo D, Yang Z, Matsumura Y, Johnson AE, Skach WR. Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon. Mol Biol Cell (2009) 20, 685-698
  8. Matsumura Y, Ban N, Inagaki N. Aberrant catalytic cycle and impaired lipid transport into intracellular vesicles in ABCA3 mutants associated with nonfatal pediatric interstitial lung disease. Am J Physiol Lung Cell Mol Physiol (2008) 295, L698-L707
  9. Kodaira Y, Kusumoto T, Takahashi T, Matsumura Y, Miyagi Y, Okamoto K, Shidoji Y, Sagami H.Formation of lipid droplets induced by 2,3-dihydrogeranylgeranoic acid distinct from geranylgeranoic acid. Acta Biochim Pol (2007) 54, 777-782
  10. Matsumura Y, Kidokoro T, Miyagi Y, Marilingaiah NR, Sagami H.The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis. J Biochem (2007) 142, 533-5370
  11. Miyagi Y, Matsumura Y, Sagami H. Human geranylgeranyl diphosphate synthase is an octamer in solution. J Biochem 142, 377-381
  12. *Yokota T, *Matsumura Y, Ban N, Matsubayashi T, Inagaki N. (*Equally contributed.) Heterozygous ABCA3 mutation associated with non-fatal evolution of respiratory distress. Eur J Pediatr (2008) 167, 691-693
  13. Matsumura Y, Sakai H, Sasaki M, Ban N, Inagaki N. ABCA3-mediated choline-phospholipids uptake into intracellular vesicles in A549 cells. FEBS Lett. (2007) 581, 3139-3144
  14. Sakai H, Tanaka Y, Tanaka M, Ban N, Yamada K, Matsumura Y, Watanabe D, Sasaki M, Kita T, Inagaki N. ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain. J Biol Chem (2007) 282, 19692-19699
  15. Ban N, Matsumura Y, Sakai H, Takanezawa Y, Sasaki M, Arai H, Inagaki N.ABCA3 as a lipid transporter in pulmonary surfactant biogenesis. J Biol Chem (2007) 282, 9628-9634
  16. Matsumura Y, Ban N, Ueda K, Inagaki N. Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency. J Biol Chem (2006) 281, 34503-34514
  17. Matsumura Y, Kuzuguchi T, Sagami H. Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level. J Biochem. (2004) 136, 301-312
  18. Szabo CM, Matsumura Y, Fukura S, Martin MB, Sanders JM, Sengupta S, Cieslak JA, Loftus TC, Lea CR, Lee HJ, Koohang A, Coates RM, Sagami H, Oldfield E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem (2002) 45, 2185-2196

 

所属学会

日本分子生物学会